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Xifapill, a prescription drug, is manufactured in various forms such as Tablet. Hepatic Encephalopathy are some of its major therapeutic uses. Xifapill also has some secondary and off-label uses. These are listed below.
The correct dosage of Xifapill depends on the patient's age, gender, and medical history. The condition it has been prescribed for, and the route of administration also determine the right dosage. Refer to the dosage section for a detailed discussion.
The side effects typically associated with Xifapill include Flatulence, Bloating or fullness, Constipation. Apart from the aforementioned side effects, Xifapill can also lead to other problems, which have been listed below. Such side effects of Xifapill normally do not last long and go away once the treatment is completed. However, if these continue for a longer time, consult your doctor right away.
It is also important to note that Xifapill has a Severe effect for pregnant women and Severe effect on lactating mothers. Further, the section on Xifapill related warnings talks about Xifapill's effects on the liver, heart and kidney.
Other conditions have been mentioned below in the Xifapill contraindications section.
Drug interactions for Xifapill have been reported in the medical literature. A complete list of these interactions is given below.
You should also be aware that Xifapill is safe while driving, and is addiction.
Xifapill is used to treat the following -
Main Benefits
Other Benefits
This is the usual dosage recommended in most common treatment cases. Please remember that every patient and their case is different, so the dosage can be different based on the disease, route of administration, patient's age and medical history.
Find the right dosage based on disease and age
| Age Group | Dosage |
| Adult |
|
| 13 - 18 years (Adolescent) |
|
| Geriatric |
|
Is the use of Xifapill safe for pregnant women?
Xifapill should not be taken during pregnancy, or should only be taken on the advice of a doctor as it may have severe side effects.
Is the use of Xifapill safe during breastfeeding?
Xifapill may cause serious side effects in breastfeeding women, so do not take this drug without doctor's advice.
What is the effect of Xifapill on the Kidneys?
Using Xifapill does not have any harmful effects on kidneys.
What is the effect of Xifapill on the Liver?
Very few cases of side effects of Xifapill on the liver have been reported.
What is the effect of Xifapill on the Heart?
Xifapill is not harmful for the heart.
Xifapill should not be taken with following medicines due to severe side effects it may cause to patients -
Moderate
If you are suffering from any of the following diseases, you should not take Xifapill unless your doctor advises you to do so -
Is this Xifapill habit forming or addictive?
No, there is no any evidence that Xifapill is addictive.
Is it safe to drive or operate heavy machinery when consuming?
Yes, it is safe to do these activities or work after taking Xifapill as it does not make you drowsy.
Is it safe?
Yes, Xifapill is safe but you must consult your doctor before taking it.
Is it able to treat mental disorders?
No, Xifapill cannot treat any kind of mental disorder.
Interaction between Food and Xifapill
You can take Xifapill with food.
Interaction between Alcohol and Xifapill
No research has been done on this till date. Therefore, it is not known what the effect of taking Xifapill with alcohol will be.
Yes, Xifapill might cause a headache. It is a rare side effect of this drug. However, the exact cause of a headache is still unknown. If you experience a severe headache after taking this drug, take a mild painkiller, apply balm and take rest even after this if the pain does not subside then discuss with your doctor without any further delay.
No, Xifapill is a prescription drug and an antibiotic, hence do not take this drug without consulting doctor to avoid bacterial resistance and unpleasant side effects. It can be harmful for patients to take this medicine without the doctor's advice.
The use of Xifapill for the treatment of small intestinal bacterial overgrowth (SIBO) is not approved and scientific evidence supporting its use for SIBO is not sufficient.
No, Xifapill does not cause weight gain. It has not been reported by the patients who are taking this drug but Xifapill has been reported to cause weight loss in a few patients with travelers’ diarrhea. If you notice any unusual rapid weight changes after taking this drug then discuss with it your doctor and follow his/her instructions.
Xifapill works by inhibiting the bacterial protein synthesis which is essential for bacterial growth. The absence of these proteins results in stunned bacterial growth due to which bacteria is not able to survive. For hepatic encephalopathy Xifapill works by inhibiting the growth of enteric ammonia-producing bacteria which are present in our gut, this results in the indirect reduction of serum ammonia level. In irritable bowel syndrome with diarrhea, how Xifapill works are still unknown but it is presumed that it works by changing the bacterial flora in small intestine and reduction in gas.
This medicine data has been created by -
References
US Food and Drug Administration (FDA) [Internet]. Maryland. USA; Package leaflet information for the user; Xifaxan® (rifaximin)
KD Tripathi. [link]. Seventh Edition. New Delhi, India: Jaypee Brothers Medical Publishers; 2013: Page No 681-683
April Hazard Vallerand, Cynthia A. Sanoski. [link]. Sixteenth Edition. Philadelphia, China: F. A. Davis Company; 2019: Page No 1096-1097
