Dr. Manoj Meena MBBS , General Physician

Lactic acidosis associated with Midamet treatment is a rare but fatal adverse effect. Lactic acidosis appears to result from biguanide interference causing an increase in production and decrease in clearance of lactate leading to higher cellular lactate levels. A decrease in pyruvate carboxylase activity, the rate-limiting enzyme in the formation of glucose from lactate, can also decrease hepatic metabolism of lactate. leading to increasing lactic acidosis. Signs and symptoms of Midamet induced lactic acidosis are nonspecific and include anorexia, nausea, vomiting, altered level of consciousness, hyperpnoea, abdominal pain, and thirst. 

Dr. Ram Saini MD, MBBS , General Physician

Midamet can be taken forever, diabetes is a progressive disease it's possible that more medication and/or insulin may eventually need to be added to the regime. 

Dr. Sameer Awadhiya MBBS , Pediatrics

Midamet helps in weight loss by reducing appetite and food intake. It also increases the insulin sensitivity in your body to work more effectively. This lead to decreased glucose production increases the use of glucose and decrease the fat deposition further helps in weight loss. However, Midamet is not approved for weight loss, this is an off-label use.

Dr. Ramraj MBBS , Other

Yes, Midamet can cause low blood sugar (hypoglycemia). However, this can also occur if you delay or miss a meal, drink alcohol, exercise more than usual, can't eat due to stomach upset, and taking other antidiabetic medicine with metformin. So, regular monitoring of blood glucose level is needed and be cautious of symptoms of hypoglycemia, always keep glucose-rich food with you. 

Dr. Haleema Yezdani MBBS , General Physician

Midamet is used with a proper diet and exercise program, to treat diabetes. It is also used with other medication to reduce the high blood sugar. It is used in a patient with type2 diabetes. It is also used in the treatment of polycystic ovarian syndrome (PCOS) and cancer.