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Acoxal 50 mg Injection contains Oxaliplatin, a platinum-based chemotherapy drug used to treat colon and rectal cancers. It works by inhibiting the growth of cancer cells.
Uses:
Oxaliplatin is a platinum-based chemotherapy drug that exerts its anticancer effects by interfering with the DNA of cancer cells. The mechanism of action involves the following steps:
DNA Intercalation and Crosslinking: Oxaliplatin is taken up by the cancer cell and undergoes conversion into its active form. It binds to the DNA in the cell, creating both intra- and inter-strand crosslinks in the DNA structure.
Inhibition of DNA Replication and Transcription: These crosslinks prevent the DNA from unwinding and replicating properly, which interferes with the cell's ability to replicate its genetic material and divide. This leads to the inhibition of DNA replication and transcription.
Induction of Apoptosis: The DNA damage caused by oxaliplatin triggers cellular mechanisms that induce programmed cell death (apoptosis). This process ultimately kills the cancer cell and helps to control tumor growth.
Platinum-DNA Adduct Formation: Oxaliplatin forms platinum-DNA adducts, which are highly cytotoxic. These adducts further prevent proper cell division and cause cell cycle arrest at various checkpoints.
Oxaliplatin is particularly effective in treating colorectal cancer due to its ability to damage cancerous cells, leading to their death and preventing tumor progression.
Dosage and Administration:
Acoxal 50 mg Injection is administered intravenously by a qualified healthcare professional. The dosage and frequency are determined by the treating physician based on the patient's condition. It is crucial to follow the doctor's instructions precisely to avoid serious side effects.
Common Side Effects:
Most side effects do not require medical attention and may subside as the body adjusts to the medication. However, consult your doctor if they persist or cause concern.
Warnings and Precautions:
Storage:
Store in a refrigerator (2°C – 8°C). Do not freeze. Keep the vial in the outer carton to protect from light.
Acoxal is used to treat the following -
Main Benefits
Other Benefits
This is the usual dosage recommended in most common treatment cases. Please remember that every patient and their case is different, so the dosage can be different based on the disease, route of administration, patient's age and medical history.
Find the right dosage based on disease and age
Age Group | Dosage |
Adult |
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Geriatric |
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Is the use of Acoxal safe for pregnant women?
Acoxal should not be taken during pregnancy, or should only be taken on the advice of a doctor as it may have severe side effects.
Is the use of Acoxal safe during breastfeeding?
Acoxal should not be taken without taking your doctor's advice, as it may have severe side effects on breastfeeding women.
What is the effect of Acoxal on the Kidneys?
Acoxal rarely harms the kidneys.
What is the effect of Acoxal on the Liver?
Acoxal may cause harmful effects on liver. if you feel it's having any such effect, then stop taking this drug, and restart only on your doctor's advice.
What is the effect of Acoxal on the Heart?
You may experience side effects on your heart after taking Acoxal. If this happens, then discontinue its use. Consult your medical practitioner, and do as he/she suggests.
Acoxal should not be taken with following medicines due to severe side effects it may cause to patients -
Severe
Moderate
If you are suffering from any of the following diseases, you should not take Acoxal unless your doctor advises you to do so -
Is this Acoxal habit forming or addictive?
Acoxal does not cause addiction.
Is it safe to drive or operate heavy machinery when consuming?
After taking Acoxal you may feel sleepy. So it is not advised to perform these activities.
Is it safe?
Yes, but take Acoxal only as per medical advice.
Is it able to treat mental disorders?
No, Acoxal cannot treat any kind of mental disorder.
Interaction between Food and Acoxal
It is safe to take Acoxal with food.
Interaction between Alcohol and Acoxal
Consult your doctor before consuming alcohol while taking Acoxal as it can have severe side effects.
This medicine data has been created by -
B.Pharma, Pharmacy
5 Years of Experience