What is Vitamin B1 (Thiamine) Urine test?

The vitamin B1 (thiamine) urine test measures the amount of vitamin B1 in your urine.

Thiamine is a water-soluble vitamin that helps maintain various metabolic functions in the body. It also plays an important role in the growth and development of cells.

vitamin B1 is mostly absorbed through food inside the small intestine and is stored in the liver in small quantities. However, it has a short half-life - it is quickly eliminated along with urine - making it important to replenish it through dietary sources. B1 is naturally obtained from meat (especially pork), fish and whole grains. This vitamin is also present in some fortified foods such as bread and cereals.

Calculating the amount of vitamin B1 in the urine primarily helps to know about the total and needed vitamin B1 intake. Though, it does not give information on the amount of vitamin B1 stored in tissues.

  1. Why is Vitamin B1 (Thiamine) Urine test performed?
  2. How do you prepare for Vitamin B1 (Thiamine) Urine test?
  3. How is Vitamin B1 (Thiamine) Urine test performed?
  4. Vitamin B1 (Thiamine) Urine test results and normal range

This test is performed to get information on whether you are getting enough thiamine from dietary consumption.

Your doctor may order this test if you show the symptoms of thiamine deficiency. The initial symptoms seen in thiamine deficiency are as follows:

Some of the following symptoms develop over time:

Sometimes a person with thiamine deficiency goes on to develop conditions like Wernicke–Korsakoff syndrome, wet beriberi or dry beriberi, the symptoms of which are as follows. 

Symptoms of Wernicke–Korsakoff syndrome are:

  • Loss of memory
  • Hallucinations
  • Confusion between real and imagined memories

Symptoms of wet beriberi include:

Symptoms of dry beriberi are:

  • Nerve problems:
    • Polyneuritis (peripheral nerve changes)
    • Numbness and tingling of toes
    • Burning feeling in feet
  • Muscle problems: Pain in the legs, muscle cramps and wasting (atrophy)

Certain people have a higher risk of having inadequate vitamin B1. These include:

  • People with chronic alcohol use disorders
  • Older adults
  • People with AIDS/HIV
  • People with diabetes
  • People who underwent bariatric surgery for weight loss

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You do not need to prepare for this test.

Vitamin B1 urine test is performed on a 24-hour sample (as opposed to a random urine sample) as it is more reliable.

You will be provided with a special container for sample collection. Your doctor may give you the following instructions for collecting and storing the urine sample:

  • It is best to begin sample collection in the morning.
  • Do not collect the first urine of the day but record the time as the beginning of the 24-hour period.
  • Through the next 24 hours, you will have to collect a urine sample every time you empty your bladder. 
  • In between sample collection, store the urine container in the refrigerator or an icebox.
  • At the end of 24 hours, return the container to the laboratory as instructed.
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Normal results:

In adults, the acceptable value of vitamin B1 in the urine is 100 fg (femtogram = 10−15 g) per 24 hours. It indicates a low risk of developing vitamin B1 deficiency conditions.

Abnormal results:

If your urine thiamine levels are in the range of 40-99 fg per 24 hours, it means that you are at a moderate risk of developing conditions related to B1 deficiency. 

However, if you release less than 40 fg thiamine per 24 hours in urine, it could be an indication of B1 deficiency.

Disclaimer: All results must be clinically correlated with the patient’s complaints to make a complete and accurate diagnosis. The above information is provided from a purely educational point of view and is in no way a substitute for medical advice by a qualified doctor.

References

  1. National Heart, Lung, and Blood Institute [Internet]. Bethesda (MD): U.S. Department of Health and Human Services; Blood Tests
  2. American Pregnancy Association [internet]; Roles of Vitamin B in Pregnancy
  3. UW Health: American Family Children's Hospital [Internet]. Madison (WI): University of Wisconsin Hospitals and Clinics Authority; Vitamin B12 Test
  4. Harvard T.H. Chan. School of Public Health [internet]: Harvard University; B Vitamins
  5. Michigan Medicine: University of Michigan [internet]; Health Library
  6. National Cancer Institute [Internet]. Bethesda (MD): U.S. Department of Health and Human Services; NCI Dictionary of Cancer Terms
  7. UFHealth [internet]: University of Florida; Vitamin B12 level. Gainesville. Florida. US; Vitamin B12 level
  8. University of Rochester Medical Center [Internet]. Rochester (NY): University of Rochester Medical Center; Vitamin B Complex
  9. National Institute of Health. Office of Dietary Supplements [internet]: Bethesda (MA), US. US Department of Health and Human Services Thiamin
  10. World Health Organization [Internet]. Geneva (SUI): World Health Organization; Thiamine deficiency and its prevention and control in major emergencies
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