What is Calcitonin test? 

Calcitonin test, also referred to as human calcitonin test or thyrocalcitonin test, is used to determine the levels of the hormone calcitonin in the blood. Calcitonin is produced by special cells called C-cells in the thyroid gland -  a butterfly-shaped gland located in the throat. It is responsible for regulating the calcium levels in the body. Calcitonin levels rise above normal in two rare diseases, medullary thyroid cancer and C-cell hyperplasia, a non-cancerous condition which may or may not develop into cancer.

  1. Why is a Calcitonin test performed?
  2. How do you prepare for Calcitonin test?
  3. How is a Calcitonin test performed?
  4. Calcitonin test results and normal range

This test is advised to patients who show symptoms of medullary thyroid cancer, such as swollen lymph nodes in the neck or lumps in the front of the neck. It is also used as a screening test in individuals with a family history of medullary thyroid cancer. Calcitonin test helps in identifying the level of risk in such individuals so necessary steps can be taken to prevent the condition. 

Furthermore, this test is useful for determining the progression of medullary thyroid cancer and is helpful in monitoring the effectiveness of anti-cancer therapy in individuals who are being treated for this cancer.

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You will be asked to stop eating and drinking the night before this test. Ask your doctor if it is okay to drink water. 

Inform your doctor if you are taking any medicines, including herbs, vitamins and supplements since certain medications may interfere with test results. Also, let him/her know if you are pregnant.

For a calcitonin test, a doctor or laboratory technician will take a blood sample from a vein in your arm by inserting a needle. You may feel slight pain as the needle goes in but it will subside soon after the test. The withdrawn sample will be collected in an appropriate container - a vial or a test tube - and sent to a laboratory for further analysis.

Some people feel lightheaded after the test and get a bruise at the injection site, though, both of these are temporary and subside on their own. If the discomfort persists, check in with your doctor at the earliest.

Results of the calcitonin test vary based on age and gender. Many other factors, such as clinical history and method employed for the test may also affect the results.

Normal results:

Calcitonin hormone is measured in picograms per millilitre (pg/mL). The normal levels of calcitonin are ≤19 pg/mL for men and ≤14 pg/mL for women.

Abnormal results:

Higher than normal levels of calcitonin indicate the following:

  • Medullary thyroid cancer
  • Current therapy for medullary thyroid cancer is not working. If the treatment for medullary thyroid cancer is successful, calcitonin will drop to low levels and remain low over time. If, however, calcitonin levels are high, the doctor may order other tests, such as a thyroid scan and/or biopsy, to confirm the diagnosis.
  • Relapse of medullary thyroid cancer
  • Breast cancer, lung cancer or pancreatic cancer 

Disclaimer: All results must be clinically correlated with the patient’s complaints to make a complete and accurate diagnosis. The above information is provided from a purely educational point of view and is in no way a substitute for medical advice by a qualified doctor.

References

  1. Kaplan LA, Pesce AJ. Clinical Chemistry: Theory, Analysis, Correlation. 5th ed. (©2010). Mosby, Inc. Pp: 626.
  2. Wells SA Jr et al. Revised American Thyroid Association guidelines for the management of medullary thyroid carcinoma.. Thyroid. 2015 Jun;25(6):567-610. doi: 10.1089/thy.2014.0335.
  3. American Cancer Society [internet]. Atlanta (GA), USA; Tests for Thyroid Cancer
  4. American Thyroid Association. Falls Church, Virginia, U.S. Thyroid Cancer
  5. Hormone Health Network [Internet]. Endocrine Society; c2018. The Endocrine System
  6. National Cancer Institute [Internet]. Bethesda (MD): U.S. Department of Health and Human Services; NCI Dictionary of Cancer Terms
  7. National Heart, Lung, and Blood Institute [Internet]. Bethesda (MD): U.S. Department of Health and Human Services; Blood Tests
  8. National Organisation of Rare Disorders [Internet]. Danbury, CT, U.S. Multiple Endocrine Neoplasia Type 2
  9. UFHealth [internet]: University of Florida; Calcitonin blood test
  10. UW Health [Internet]. Madison (WI): University of Wisconsin Hospitals and Clinics Authority; Health Information: Boosting Your Metabolism
  11. University of Rochester Medical Center [Internet]. Rochester (NY): University of Rochester Medical Center; Calcitonin
  12. National Health Service [internet]. UK; Blood Tests
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