Hypospadias is a birth defect or congenital condition in boys where the opening of the urethra doesn't line up or end up at the tip of the penis. The penis is the outlet from where urine and sperm are released from the body, and this misalignment occurs between the eighth week and 14th week of pregnancy.
Although it is considered to be a rare phenomenon, the occurrence of this pediatric urological disorder has been increasing over the years. The incidence of hypospadias used to be about one in every 250 newborn boys earlier; it has increased to one out of every 150 newborn boys according to more recent studies on the subject in India.
The abnormality of this misaligned opening can be from just below the penis all the way down to the scrotum, and is clinically described by a few different types. Under normal circumstances, the opening of the urethra is located within the head of the penis.
Here is how it happens: It is between the eighth and 14th weeks of pregnancy that the sex development of the baby is taking place inside the womb of the mother, as the sexual organs look similar until then. It is only during this period when the male hormones are produced by the testes - such as testosterone and Dihyodrotestosterone - that the sexual organs start developing into pronounced male organs.
This complex phenomenon taking place inside the womb through the production of hormones is what gives the penis its final shape and the urethra develops simultaneously, to line up with the opening of the penis. Any shortage in the production of hormone levels that are needed for this development can result in the occurrence of hypospadias, as the urethra doesn't end up at the tip (glans) of the penis.
In some cases, hypospadias are also clinically related or occur together with undescended testicles, or result in low sperm count, or even testicular cancer later in life. In recent years, the prevalence of hypospadias has increased to about one in 126 newborn boys in the country, while the occurrence of undescended testicles is even more at a rate of about 5%.
Some boys with hypospadias may have curved penises as a result, and it can have more complications later in life such as unusual spraying of urine, sometimes to the extent that they may have to sit down to urinate. However, it is one of the more common birth defects in newborn boys, and early treatment is recommended to avoid problems later in life.