As of 28 March 2020, COVID-19, first reported in the Chinese city of Wuhan in December 2019, has infected more than 6 lakh people around the globe, killing more than 27,000 people.

Though the virus can affect all generations, people above the age of 65 years and those with some pre-existing medical conditions are more prone to get severe symptoms of the disease. Reports have stated that amongst those who died, 90% of them had some underlying medical condition. As per China’s public health report on 17 March 2020, out of the 355 people who died due to COVID-19, 33% of them had pre-existing heart disease.

People with diabetes, asthma, heart disease, kidney disease and high blood pressure are considered to be at a higher risk of getting the COVID-19 infection. 

Here in this article, we will tell you how people with a history of high blood pressure are prone to get severe symptoms of COVID-19 infection and what can be done to prevent it.

  1. Action of Angiotensin-converting enzyme-II (ACE-II) on blood pressure
  2. High blood pressure and COVID-19
  3. Maintaining blood pressure during COVID-19
  4. Takeaway
Doctors for How COVID-19 affects people with high blood pressure

There is a system called the renin-angiotensin system, which controls the blood pressure, fluid and electrolyte balance of the body. Renin breaks down the enzyme angiotensinogen to form angiotensin I whenever the blood pressure of the body drops down. 

Since angiotensin-I is an inactive protein, it converts into the active form angiotensin-II with the help of the angiotensin-converting enzyme (ACE).

ACE-II is found in large quantities in the lining of lungs, intestines, kidneys and blood vessels. 

Whenever there is low blood pressure, ACE-II binds with the ACE receptors and constricts the blood vessels. This helps in raising the blood pressure of the body.

A rise in the levels of ACE-II in people with cardiovascular diseases like heart attack, high blood pressure, and chronic kidney disease, increases the risk of a sudden spike in their blood pressure. To prevent this, doctors prescribe angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) to these people.

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Scientists have found out that in order to invade a cell, COVID-19 virus, also called the SARS-CoV-2, attaches itself on angiotensin-converting enzyme-II (ACE-II). 

By invading ACE-II, the virus gets easy access to the lungs. By invading the cells of the respiratory tract, they start presenting symptoms like cough, sore throat and shortness of breath.

Since the levels of ACE-II increases in the blood vessels of people with high blood pressure, the virus attacks these blood vessels more brutally.

This is the reason why people with high blood pressure are prone to get more severe symptoms as compared to healthy individuals.

These steps can reduce the risk of getting high blood pressure in a person during COVID-19 infection: 

  • Stock the medications: Make sure you have all your necessary medications at home as you might not be able to step out of your house for days.
  • Exercise daily: Since you cannot go out of your house, you can do light exercises while staying at home. You can do basic exercises like stretching, walking and or some yoga asanas for at least 30 minutes a day. 
  • Check your blood pressure: Monitor your blood pressure once daily with the help of an automatic blood pressure machine. 
  • Quit smoking: The chemicals in the tobacco increase the blood pressure. So in order to prevent this, you should quit smoking.
  • Eat healthy food: High salt diet should be totally avoided. Avoid high-calorie snacks. Eat fibre-rich food, low-fat dairy products like milk and yoghurt, food items rich in magnesium and potassium to help your body regulate blood pressure.
  • Stay stress-free: Stress is one of the major reasons for the spike in blood pressure in the body. Stay calm and take good care of your health. 
  • Consult a doctor: If you feel you are getting any of the symptoms of COVID-19 infection, consult your nearest doctor immediately. Call them and let them know about your situation, then proceed accordingly.
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The outbreak of the latest iteration of a coronavirus infection has thrown the daily life of people all over the world into complete disarray. Governments all over the world have imposed strict restrictions on the public with regards to movement to arrest the rising number of infections that has overwhelmed the public healthcare systems in major countries like Italy, Spain as well as the United States.

Global leaders have stressed on people remaining indoors to be able to prepare for the onslaught of rising number of people coming through hospital doors for treatment. In the public's part, maintaining a healthy life while remaining indoors becomes tantamount. With a practice of a regular routine of a balanced diet, regular exercise and checking for vital health parameters, one can be able to tide through these difficult times.

Dr. Narayanan N K

Dr. Narayanan N K

Endocrinology
16 Years of Experience

Dr. Tanmay Bharani

Dr. Tanmay Bharani

Endocrinology
15 Years of Experience

Dr. Sunil Kumar Mishra

Dr. Sunil Kumar Mishra

Endocrinology
23 Years of Experience

Dr. Parjeet Kaur

Dr. Parjeet Kaur

Endocrinology
19 Years of Experience


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References

  1. James PA, Oparil S, Carter BL, et al. 2014 James PA, Oparil S, Carter BL, et al. 2014 Evidence-Based Guideline for the Management of High Blood Pressure in Adults: Report From the Panel Members Appointed to the Eighth Joint National Committee (JNC 8). JAMA. 2014;311(5):507–520. doi:10.1001/jama.2013.284427NC 8). JAMA. 2014;311(5):507–520. doi:10.1001/jama.2013.284427
  2. Louisiana State University Health Sciences Center. ACE inhibitors and angiotensin receptor blockers may increase the risk of severe COVID-19, paper suggests. ScienceDaily. ScienceDaily, 23 March 2020.
  3. Zheng, Y., Ma, Y., Zhang, J. et al. COVID-19 and the cardiovascular system. Nat Rev Cardiol (2020). https://doi.org/10.1038/s41569-020-0360-5
  4. Science Direct (Elsevier) [Internet]; Are patients with hypertension and diabetes mellitus at increased risk for COVID-19 infection?
  5. Johns Hopkins Medicine [Internet]. The Johns Hopkins University, The Johns Hopkins Hospital, and Johns Hopkins Health System; Hypertension: What You Need to Know as You Age
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